Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency
✍ Scribed by Brad Barker; Fevzi Altuntas; Geeta Paranjape; Ravindra Sarode
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 59 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0733-2459
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✦ Synopsis
Abstract
In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post‐exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery. J. Clin. Apheresis 19:208–210, 2004. © 2004 Wiley‐Liss, Inc.