Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: First case report
✍ Scribed by Masahiko Suzuki; Nobutaka Hattori; Satoshi Orimo; Nobuyoshi Fukumitsu; Masahiro Abo; Yu Kono; Renpei Sengoku; Akira Kurita; Hidehiko Honda; Kiyoharu Inoue
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0885-3185
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✦ Synopsis
Abstract
A decrease in myocardial uptake of iodine‐123–labeled metaiodobenzylguanidine (^123^I‐MIBG) has been reported in idiopathic Parkinson's disease (PD) using ^123^I‐MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR‐JP), caused by the parkin gene, presented here showed normal ^123^I‐MIBG myocardial uptake, suggesting that AR‐JP is a distinct disease entity from PD. Although the clinical features of AR‐JP are sometimes quite similar to those of late‐onset idiopathic PD, ^123^I‐MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR‐JP. © 2005 Movement Disorder Society