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Preservation of the active lactone form of irinotecan using drug eluting beads for the treatment of colorectal cancer metastases

✍ Scribed by Yiqing Tang; Peter R. Czuczman; Shui T. Chung; Andrew L. Lewis


Book ID
113691696
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
759 KB
Volume
127
Category
Article
ISSN
0168-3659

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## Abstract We investigated the therapeutic efficiency of sulfonate‐modified polyvinyl alcohol beads loaded with doxorubicin, irinotecan or mitoxantrone __in vitro__ and __in vivo__ in a model of experimental peritoneal carcinomatosis (PC). __In vitro__, cell proliferation was efficiently impaired