Preservation of morphology and function of guinea pig pancreatic islet cells in subculture
β Scribed by M. E. Basmadzhyan; V. I. Gevorkyan; N. F. Gusakova; I. I. Martirosyan; G. A. Kazaryan; A. S. Ambartsumyan
- Publisher
- Springer US
- Year
- 1983
- Tongue
- English
- Weight
- 658 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0007-4888
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Islet cell lines were produced by retroviral transduction of SV-40 T antigen to monolayer cultures of neonatal rat islets. One line, RN0-11, showed evolution of phenotypes in vitro. It evolved from a non-hormone secreting cell line to an insulin secreting line. It further developed glucagon producin
Pancreatic islets are enveloped by a sheath of Schwann cells, the glial cells of the peripheral nervous system (PNS). The fact that Schwann cells of the PNS become reactive and express nerve growth factor (NGF) and other growth factors following axotomy suggested the possibility that peri-islet Schw