## Abstract Intravascular lymphomatosis (IVL) is a rare systemic disease characterized by proliferation of lymphoid cells within the lumina of small arteries, veins, and capillaries. Diagnosis requires skin, liver, lung, bone marrow, renal, meningeal, or brain vessel biopsy but is often made only w
Presentation of intravascular lymphomatosis as lumbosacral polyradiculopathy
โ Scribed by Satu Viali; David O. Hutchinson; Timothy E. Hawkins; Margaret C. Croxson; Mark Thomas; Jonathan P. Allen; Stephen M. Thomas; Kevin H. Powell
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 211 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0148-639X
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โฆ Synopsis
A 53-year-old man developed progressive sensory disturbance and weakness in the legs, sphincter disturbance, back pain, systemic symptoms, and pancytopenia. Electrophysiological tests indicated a widespread lumbosacral polyradiculopathy. Spinal magnetic resonance imaging and routine cerebrospinal fluid analysis showed minor nonspecific abnormalities. Bone marrow and liver biopsies showed hemophagocytosis; and polymerase chain reaction of cerebrospinal fluid, bone marrow, and serum suggested active infection with human herpesvirus-6. Autopsy revealed that his neurological symptoms resulted from intravascular lymphomatosis (angiotropic large cell lymphoma), a rare variant of lymphoma with predilection for the nervous system.
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