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Presentation of intravascular lymphomatosis as lumbosacral polyradiculopathy

โœ Scribed by Satu Viali; David O. Hutchinson; Timothy E. Hawkins; Margaret C. Croxson; Mark Thomas; Jonathan P. Allen; Stephen M. Thomas; Kevin H. Powell


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
211 KB
Volume
23
Category
Article
ISSN
0148-639X

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โœฆ Synopsis


A 53-year-old man developed progressive sensory disturbance and weakness in the legs, sphincter disturbance, back pain, systemic symptoms, and pancytopenia. Electrophysiological tests indicated a widespread lumbosacral polyradiculopathy. Spinal magnetic resonance imaging and routine cerebrospinal fluid analysis showed minor nonspecific abnormalities. Bone marrow and liver biopsies showed hemophagocytosis; and polymerase chain reaction of cerebrospinal fluid, bone marrow, and serum suggested active infection with human herpesvirus-6. Autopsy revealed that his neurological symptoms resulted from intravascular lymphomatosis (angiotropic large cell lymphoma), a rare variant of lymphoma with predilection for the nervous system.


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## Abstract Intravascular lymphomatosis (IVL) is a rare systemic disease characterized by proliferation of lymphoid cells within the lumina of small arteries, veins, and capillaries. Diagnosis requires skin, liver, lung, bone marrow, renal, meningeal, or brain vessel biopsy but is often made only w