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Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44

✍ Scribed by Murakami, Daizo; Okamoto, Isamu; Nagano, Osamu; Kawano, Yoshiaki; Tomita, Taisuke; Iwatsubo, Takeshi; De Strooper, Bart; Yumoto, Eiji; Saya, Hideyuki

Book ID
110067413
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
290 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract The presenilin/γ‐secretase protease cleaves many type‐I membrane proteins, including the amyloid β‐protein (Aβ) precursor (APP). Previous studies have shown that apoptosis induces alterations in Aβ production in a caspase‐dependent manner. Here, we report that staurosporine (STS)‐induce