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Presenilin 1 is essential for cardiac morphogenesis

✍ Scribed by Mitsunari Nakajima; Eiko Moriizumi; Haruhiko Koseki; Takuji Shirasawa

Book ID
102153850
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
277 KB
Volume
230
Category
Article
ISSN
1058-8388

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✦ Synopsis

Abstract

Presenilin 1 (PS1) is the gene responsible for the development of early‐onset familial Alzheimer's disease. PS1‐deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1‐deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using anti‐PS1 antibody revealed the prominent expression of PS1 in mesenchymal cells at the septal area of the wild‐type heart. These results suggest that PS1 may play an essential role in heart development. Developmental Dynamics 230:795–799, 2004. Β© 2004 Wiley‐Liss, Inc.

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