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Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat

โœ Scribed by Peter Kasa; Henrietta Papp; Magdolna Pakaski

Book ID
113997325
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
952 KB
Volume
909
Category
Article
ISSN
0006-8993

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Both N-terminal and C-terminal fragments
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Presenilin 1 (PS1) is a causative gene for chromosome 14-linked familial Alzheimer's disease. The gene product is known to be cleaved into N-terminal fragments (PS1-N) and C-terminal fragments (PS1-C). To understand the pathophysiological role of PS1, we conducted immunohistochemical studies using a