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Presence of the toxic metabolite N-hydroxy-norcocaine in brain and liver of the mouse

✍ Scribed by Myron Benuck; Maarten E.A. Reith; Abel Lajtha

Book ID
115780519
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
427 KB
Volume
37
Category
Article
ISSN
0006-2952

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✍ Silvia Romão; Silvia M. S. C. Cadena; Juliana C. Amorim; Stelia C. Méndez-Sánche 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 528 KB

## Abstract The mesoionic derivative 4‐phenyl‐5‐[4‐nitrocinnamoyl]‐1,3,4‐thiadiazolyl‐2‐phenylamine chloride (MI‐D) has antitumoral and anti‐inflammatory effects. In this study, we present aspects of its metabolism and toxicity in mice. MI‐D was metabolized __in vitro__ by liver microsome, generati