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Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: Compounds related to Parkinson's disease

✍ Scribed by Yukiko Makino; Shigeru Ohta; Osamu Tachikawa; Masaaki Hirobe

Book ID
118342903
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
260 KB
Volume
43
Category
Article
ISSN
0024-3205

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### 9.1. 90) (5)-Norcoclaurine-I-carboxylic acid (5) and the derived dihydroisoquinolinone 6 (present as quinonemethide 6a at pH 7) afforded, on methylation with I4C-labeled S-adenosyl-L-methionine in the presence of mammalian catechol 0 methyitransferase, exclusively the 7-0-methylated congeners 7

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## Abstract Tetrahydropapaveroline (THP) is a compound derived from dopamine monoamine oxidase–mediated metabolism, particularly present in the brain of parkinsonian patients receiving L‐dopa therapy, and is capable of causing dopaminergic neurodegeneration. The aim of this work was to evaluate the