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Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas

✍ Scribed by Marie-Pierre Chenard; Yves Lutz; Agnés Mechine-Neuville; Isabelle Stoll; Jean-Pierre Bellocq; Marie-Christine Rio; Paul Basset

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
203 KB
Volume
82
Category
Article
ISSN
0020-7136

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✦ Synopsis

Matrix metalloproteinase 2 (MMP2) activity is associated with the aggressiveness of human cancers. Therefore, the mechanisms regulating its activation are of great interest for a better understanding of malignant invasive processes. MT1-MMP, a membrane-bound MMP, is involved in the conversion of the latent form of MMP2 to the active one. In the present study, we have raised 3 monoclonal antibodies (Mabs) directed against 3 different epitopes of human MT1-MMP, which we used to investigate the expression and cellular localization of MT1-MMP protein in human carcinomas. MT1-MMP protein was present in all invasive carcinomas tested, and it was almost exclusively located to the stromal cells and not to cancer cells as previously reported, suggesting that MMP2 activation might be a peri-fibroblastic event.

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