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Presence of endometrial adenocarcinoma in situ in complex atypical endometrial hyperplasia is associated with increased incidence of endometrial carcinoma in subsequent hysterectomy

✍ Scribed by Mittal, Khush; Sebenik, Matjaz; Irwin, Cybil; Yan, Zhijije; Popiolek, Dorota; Curtin, John; Palazzo, Juan

Book ID: 109887563
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 458 KB
Volume: 22
Category: Article
ISSN: 0893-3952
DOI: 10.1038/modpathol.2008.138

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## Abstract Loss of DNA mismatch repair occurs in a variety of malignancies and is associated with genome‐wide instability of microsatellite repeats, a molecular phenotype referred to as microsatellite instability (MSI). MSI is a consistent feature of colorectal and endometrial tumors from patients