Presence of Certain Onium Compounds in Brain Tissue following intravenous Administration to Rats
โ Scribed by LEVINE, RUTH R.
- Book ID
- 109603505
- Publisher
- Nature Publishing Group
- Year
- 1959
- Tongue
- English
- Weight
- 373 KB
- Volume
- 184
- Category
- Article
- ISSN
- 0028-0836
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๐ SIMILAR VOLUMES
Intranasal (IN) administration as a potential route of enhancing brain delivery of stavudine (d4T) was investigated in rats using microdialysis as a sampling technique. Sprague-Dawley rats were divided into two groups (n = 7 per group). One group of animals received IN administration of 5 mg/kg d4T
H-labeled physostigmine (50 pg. kg-') was administered intravenously to rats, and its concentration in brain tissue and spinal cord was assessed by quantitative autoradiography. Regional cerebral blood flow (rCBF) was measured with i~do-'~C-antipyrine autoradiography in control rats and in animals i