Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis

Effector CD8+ T cells in systemic sclero

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis

✍ Patrizia Fuschiotti; Thomas A. Medsger Jr.; Penelope A. Morel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 1 views

## Abstract ## Objective T lymphocytes play an important role in systemic sclerosis (SSc), a connective tissue disease characterized by inflammation, fibrosis, and vascular damage. While their precise role and antigen specificity are unclear, T cell–derived cytokines likely contribute to the induc