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Preparative separation of amino acid enantiomers as N-TFA, O-isopropyl derivatives by continuous countercurrent gas-liquid chromatography

✍ Scribed by Katsuya Sato; Katsunori Watabe; Toshihide Ihara; Dr. Toshiyuki Hobo

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 307 KB
Volume: 5
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530050411

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✦ Synopsis

Abstract

Preparative separation of derivatives of amino acid enantiomers was carried out by a countercurrent gas–liquid chromatography (CCGLC) with chiral liquid phases, N‐stearoyl‐L‐valine tert‐butylamide and/or N‐stearoyl‐L‐leucine tert‐butylamide. In order to make effective use of these phases and also to lower the viscosity, Apiezon C was added as diluent. Through a repeated operation of a temperature gradient, purities more than 99% of leucine and α‐amino butyric acid derivatives were proved to be obtained. © 1993 Wiley‐Liss, Inc.

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