✦ LIBER ✦

Preparative scale enantioseparation of 1-cyclohexyl-1-phenylethyl hydroperoxide and 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide on a modified cellulose stationary phase

✍ Scribed by Dr. Jürgen Wagner; Hans-Jürgen Hamann; Werner Döpke; Annamarie Kunath; Eugen Höft

Book ID: 102072186
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 407 KB
Volume: 7
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530070410

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✦ Synopsis

The analytical and preparative scale optical resolution of 1-cyclohexyl-1phenylethyl hydroperoxide and 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide has been achieved by chiral HPLC on a cellulose tris(3,5-dimethylphenyl carbamate) stationary phase coated on silica gel. The method has been used to obtain several hundred milligrams of highly enriched enantiomers (%ee >98) which were characterized by [ . I u and circular dichroism spectra, respectively. Configurational assignments were achieved for 1,2,3,4-tetrahydro-1naphthyl hydroperoxide enantiomers.

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