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Preparative liquid chromatography of 1:1 adducts derived from the reaction of malondialdehyde with amino acids

✍ Scribed by Donald J. Pietrzyk; John Stodola

Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
400 KB
Volume
117
Category
Article
ISSN
0003-2697

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✦ Synopsis

Purification of 1: 1 adducts (enaminals) formed from the reaction of methyl esters of amino acids with either malondialdehyde or methylmalondialdehyde was accomplished by preparative liquid chromatography on the stationary phase Amberlite XAD-4. The enaminal was easily and rapidly separated from the by-products and starting materials by a EtOH-HZ0 mobile phase and then easily and rapidly recovered from the EtOH-H,O at good yield and high purity. Depending on column diameter, up to 50 mg of enaminal could be purified in one chromatographic step. Adducts derived from L-Arg, L-His, L-Tyr, and L-Cys were purified.

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