✦ LIBER ✦
Preparative bioorganic chemistry, XV. Preparation of optically pure 2,4,4-trimethyl-2-cyclohexen-1-ol, a new and versatile chiral building block in terpene synthesis
✍ Scribed by Mori, Kenji ;Puapoomchareon, Prapai
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 476 KB
- Volume
- 1991
- Category
- Article
- ISSN
- 0947-3440
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Enzymatic hydrolysis of (±)‐2,4,4‐trimethyl‐2‐cyclohexenyl acetate [(±)‐3] with pig liver esterase yielded (R)‐(+)‐2,4,4‐trimethyl‐2‐cyclohexen‐1‐ol [(R)‐2] and unchanged (S)‐(−)‐acetate (S)‐3. Enantiomerically pure (S)‐2 was converted into (R)‐dihydro‐α‐ionone (10).