Preparation, structure, and solution dynamics of phenyldichloroarsine-thio sugar adducts

✍ Scribed by Kilian Dill; Sungho Hu; Richard J. O'Connor; Evelyn L. McGown

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 384 KB
• Volume: 196
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(90)84113-9

✦ Synopsis

Metal-ion derivatives of l-thio-B-D-galactose and l-thio-@D-glucose have been used or tested for medicinal purpose~~-~. The most common derivative, auranofin, the gold derivative of l-thio-P-D-glucose, has undergone worldwide testing and has been used therapeutically against rheumatoid arthritis1-3,5. The drug unfortunately has some serious clinical drawbacks1-3*5. More recently, copper derivatives of 1-thioglucose were synthesized and tested for anti-inflammatory activity4. Also, dimethylarsinous acid ester derivatives of l-and 6-thiogalactose, 2