Preparation, properties, and mathematical modeling of microparticle drug delivery systems based on biodegradable amphiphilic triblock copolymers
✍ Scribed by Guo-Ping Yan; Hua Li; Si-Xue Cheng; Steven E. Bottle; Xiao-Gui Wang; Yong Kin Yew; Ren-Xi Zhuo
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 99 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Abstract
A series of biodegradable amphiphilic A‐B‐A type triblock copolymers P(BLA‐PEG‐BLA), composed of hydrophilic poly(ethylene glycol) (PEG) as a middle block component (B) and hydrophobic poly(β‐benzyl‐L‐aspartate) as outer polypeptide block components (A), were synthesized by copolymerization of β‐benzyl‐L‐aspartate N‐carboxy anhydride (BLA‐NCA) and the diaminated PEG with the primary amino groups capped at both ends. These P(BLA‐PEG‐BLA) copolymers were characterized by ^1^H‐NMR, DSC, and GPC. The triblock copolymers were used to prepare three kinds of drug delivery systems including Norfloxacin (INN)‐incorporated P(BLA‐PEG‐BLA) microparticles and tablets. The morphologies of the microparticles were characterized by SEM. The in vitro release properties of the microparticles and tablets in PBS were also evaluated. A mathematical model, which incorporates a linear first‐order dissolution term and the transient Fickian diffusion equation, was developed to account for the kinetics of drug release from the INN‐incorporated P(BLA‐PEG‐BLA) microparticles. The results indicated that the overall release process was well controlled by both drug dissolution and diffusion. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 3869–3873, 2004