Preparation of Unsymmetrical Biaryls by Pd(II)-Catalyzed Cross-Coupling of Aryl Iodides
β Scribed by Wang, Liqiang; Lu, Wenjun
- Book ID
- 126894609
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 117 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
Unsymmetrical biaryls may be prepared in an efficient manner using aryl chlorides as substrates in Negishi-type cross-coupling reactions with arylzinc reagents via either Ni-or Pd-catalysis. Since a wide range of functional groups (e.g., nitrile, carbonyl, ester) tolerate arylzinc compounds, this m
## Abstract Aryl bromides containing a (1,4,5,6βtetrahydroβ6βoxopyridinβ3βyl)methyl substituent can be coupled with aryl halides yielding unsummetrical biaryls. In the course of this process, the cyclic enamide is oxidized to the 2(1__H__)βpyridinone. The reaction proceeds by a sixβmembered pallada