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Preparation of Unsymmetrical Biaryls by Pd(II)-Catalyzed Cross-Coupling of Aryl Iodides

✍ Scribed by Wang, Liqiang; Lu, Wenjun


Book ID
126894609
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
117 KB
Volume
11
Category
Article
ISSN
1523-7060

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Preparation of unsymmetrical biaryls via
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Unsymmetrical biaryls may be prepared in an efficient manner using aryl chlorides as substrates in Negishi-type cross-coupling reactions with arylzinc reagents via either Ni-or Pd-catalysis. Since a wide range of functional groups (e.g., nitrile, carbonyl, ester) tolerate arylzinc compounds, this m

Unsymmetrical Biaryls by Palladium-Catal
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## Abstract Aryl bromides containing a (1,4,5,6‐tetrahydro‐6‐oxopyridin‐3‐yl)methyl substituent can be coupled with aryl halides yielding unsummetrical biaryls. In the course of this process, the cyclic enamide is oxidized to the 2(1__H__)‐pyridinone. The reaction proceeds by a six‐membered pallada