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Preparation of UDP-d-[U-14C]galacturonic acid and UDP-d-[6-3H]galactose with high specific activities

✍ Scribed by A.Kalyan Rao; Joseph Mendicino


Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
447 KB
Volume
72
Category
Article
ISSN
0003-2697

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✦ Synopsis


Simple procedures for the preparation of UDP-D-[U-'*C]galBCtUrOniC acid and UDP-D-[6+i]gatactose with high specific activities are described. The conversion involves the enzymatic oxidation of the appropriate UDP-o-galactose derivative to UDP-o-galactose-6aldehyde

followed by either further oxidation with iodine or reduction with sodium borotritide. The labeled products were isolated from reaction mixtures by ion exchange and paper chromatography.