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Preparation of Tritium-Labeled Antibiotic, Cerulenin, by Two-Phase System

✍ Scribed by F. Kurosaki; M. Itoh; A. Nishi


Book ID
102561325
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
184 KB
Volume
210
Category
Article
ISSN
0003-2697

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Yields of kinetically controlled synthesis of antibiotics catalyzed by penicillin G acylase from Escherichia coli (PGA) have been greatly increased by con- tinuous extraction of water soluble products (cephalexin) away from the surroundings of the enzyme. In this way its very rapid enzymatic hydroly