Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process.
โ Scribed by Ian R. Baxendale; Charlotte M. Griffiths-Jones; Steven V. Ley; Geoffrey K. Tranmer
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 10 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A preparative method for the preparation of large peptides is described. An advantageous theoretical weight of peptide/weight of starting resin ratio (tP w /R w ) of about 0.3 was successfully experimented. The esterification of the first amino acid was realized with a racemization of less than 1%.
Loganin an iridoid glycoside extracted from the fruit of the plant, Strychnos nux-vomica, in an earlier study showed hepatoprotection in primary screening. The present detailed study has been carried out in isolated hepatocytes (ex vivo) and on bile flow (in vivo) against galactosamine induced hepat