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Preparation of the 15,6?-lactone from 8?,13?H-tetrahydroabietic acid

โœ Scribed by Cross, Brian E.; Firth, Michael R.


Book ID
120085169
Publisher
Royal Society of Chemistry
Year
1981
Weight
398 KB
Volume
0
Category
Article
ISSN
1472-7781

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Prelog-Djerassi lactone. Preparation of
โœ Salih Hacini; Maurice Santelli ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 392 KB

The Grieco intermediate 2, for the synthesis of the Prelog-Djerassi lactone, was obtained from trans-pulegenic acid 3 in 6 steps in 43 9b overall yield; recycling unwanted diastereoisomer SCS\_I, increased the yield to 56 %. The Prelog-Djerassi lactone 1 is a key degradation product of the antibioti