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Preparation of Tetrahydroagathic Acid: A Serum Metabolite of Isocupressic Acid, a Cattle Abortifacient in Ponderosa Pine

✍ Scribed by Garrossian, Massoud; Gardner, Dale R.; Panter, Kip E.; James, Lynn F.


Book ID
120473457
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
136 KB
Volume
50
Category
Article
ISSN
0021-8561

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Binding of a metabolite of triflusal (2-
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2-hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of the platelet antiaggregant drug triflusal. Its binding to plasma proteins of rats and healthy volunteers in vitro and in vivo has been studied. Rats were given a single oral dose of 50 mg.kg-1 triflusal and the healthy vo