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Preparation of substituted 1,2-Dihydro-3H-pyrazol-3-ones from polylithiated 2′-phenylphenylacetohydrazides and aromatic esters

✍ Scribed by Jennifer R. Downs; Stefan J. Pastine; Jessica D. Townsend; Heather A. Greer; Wayne Kelley Jr.; Deborah A. Schady; Teresa Lentz Mcconaughy; Clyde R. Metz; Charles F. Beam; Catharine D. Almquist; William T. Pennington; Rosa D. Bailey Walsch

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
105 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Several 2′‐phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C‐acylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5‐trisubstituted, 1,2‐dihydro‐3__H__‐pyrazol‐3‐ones.

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