Preparation of Some MANNICH Bases from 2-amino- and 2-allylamino-4-methyl-5-acetyl-thiazole

✍ Scribed by Dr. D. Suciu

• Book ID: 105351822
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 437 KB
• Volume: 313
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/prac.19713130202

✦ Synopsis

Abstract

From 2‐amino‐(1 a) and 2‐allylamino‐4‐methyl‐5‐acetyl thiazole (2 a) and the N‐acylated compounds 1 b–f the correspondent MANNICH bases of the type RCOCH~2~CH~2~NR~2~ · HCl(NR~2~ = morpholino, piperidino, dimethylamino, diethylamino and diisopropylamino) were prepared and characterized as phenylhydrazones. The bromination of these MANNICH compounds gave α‐bromo‐β‐aminoketones.