Preparation of reactor-produced carrier-free 18F-fluoride as the potassium 18-crown-6 complex for synthesis of labelled organic compounds

Synthesis and characterization of 2,6-di

Synthesis and characterization of 2,6-difluoro-4-carboxyphenylboronic acid and a biotin derivative thereof as captors of anionic aqueous [18F]-fluoride for the preparation of [18F/19F]-labeled aryltrifluoroborates with high kinetic stability

✍ Curtis W. Harwig; Richard Ting; Michael J. Adam; Thomas J. Ruth; David M. Perrin 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 154 KB

Arylboronic esters are readily converted to aryltrifluoroborates in the presence of aqueous fluoride. As such these represent attractive synthetic precursors that afford one-step labeling with [ 18 F]-fluoride for the generation of PET reagents. Herein we present the synthesis of a heretofore undisc