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Preparation of (R)- and (S)-γ-amino-β-hydroxypropylphosphonic acid from glycine

✍ Scribed by Mario Ordóñez; Angelina González-Morales; César Ruı́z; Ricardo De la Cruz-Cordero; Mario Fernández-Zertuche

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 280 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00371-9

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✦ Synopsis

An efficient synthesis of both enantiomers of g-amino-b-hydroxypropylphosphonic acid, an analogue of GABOB, has been achieved for the first time starting from glycine, through the resolution of dimethyl (±)-3-(N,N-dibenzylamino)-2-hydroxypropylphosphonate 7 with (S)-O-methylmandelic acid.

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