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Preparation of pyrrolo[2,1,5-cd]indolizine Derivatives by intramolecular condensation of 3-acyl-5-methylindolizines

✍ Scribed by Feng Liang; Jiaxin Hu; Lande Zhang; Yuefei Hu; Hongwen Hu

Publisher: Journal of Heterocyclic Chemistry
Year: 2001
Tongue: English
Weight: 51 KB
Volume: 38
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570380408

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✦ Synopsis

Abstract

An efficient two step route has been developed to synthesize pyrrolo[2,1,5‐cd]indolizine derivatives. The reaction sequence proceeds via preparation of 3‐acyl‐5‐methylindolizines followed by an intramolecular condensation. The procedures were carried out under convenient conditions and gave the products in high yields. It could be expected to be used to prepare a broad range of potentially interesting pyrrolo[2,1,5‐cd]indolizine derivatives.

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