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Preparation of pyrimidine derivatives as potential medicinal agents by the reaction of 2-amino-4-chloro-6-methylpyrimidine with primary and secondary amines

✍ Scribed by Irwin Becker

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 115 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420707

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✦ Synopsis

Thirteen derivatives of pyrimidine were prepared as potential medicinal agents by the reaction of 2amino-4-chloro-6-methylpyrimidine with primary and secondary amines in the absence of a solvent. Six of the derivatives are piperazinylpyrimidines. The compounds prepared in this work may prove to be efficacious in the treatment of inflammation, hypertension, anxiety, depression, or cancer.

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Preparation of Pyrimidine Derivatives as

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