Preparation of poly(acrylic acid) modified polyurethane membrane for biomaterial by UV radiation without degassing

✍ Scribed by Yang, Jen-Ming ;Huang, Ming Ju ;Yeh, Ta-Sen

• Book ID: 102656413
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 739 KB
• Volume: 45
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199905)45:2<133::aid-jbm8>3.0.co;2-d

✦ Synopsis

Poly(acrylic acid) modified polyurethane (AA/ PU) membranes were prepared by UV radiation without degassing. The chemical composition of the AA/PU membrane was studied by IR spectroscopy. In addition to those absorption peaks associated with pure PU, the absorption peak at 2400 cm -1 of poly(AA) was also found. The morphology of AA/PU membrane was studied by optical polarizing microscopy. We also measured the glass transition temperature and the decomposition temperature of the AA/ PU membrane by differential scanning calorimetry and thermogravimetric analysis. A significant domain was found in the AA/PU membrane, which resulted in different glass transition temperature and decomposition temperature between AA/PU and pure PU membrane. The effect of AA content on the contact angle and water absorption of the AA/PU membrane was determined. It was found that the water content of AA/PU membrane increased with increasing AA content, whereas the contact angle decreased. By using Kaeble's equation and the contact angle data, the surface free energy of AA/PU membrane was determined. The increase of surface free energy resulted from the increase of the dispersion (␥ d ) term and polar (␥ p ) term. In order to evaluate the biocompatibility of these membranes, a cytotoxicity test and a cell adhesion and proliferation assay were conducted in cell culture. Immortal cells and primary lymphocytes were both used in this study. The results showed that these AA/PU membranes exhibited very low cytotoxicity and could support cell adhesion and growth. An animal primary test was also done in this study. It was found that the AA/PU membrane could possibly be employed in the treatment of bowel defect.