Preparation of no-carrier-added 4-[131i]iodoantipyrine using chloramine-T

✍ Scribed by Thomas E. Boothe; Ronald D. Finn; Manhar M. Vora; J Paresh Kothari; Ali M. Emran

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: French
• Weight: 259 KB
• Volume: 23
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580230504

✦ Synopsis

The blood f l o w reagent 4-iodoantipyrine, l a b e l l e d w i t h 13'1 o r lZ5I, was prepared by a l l o w i n g aqueous a n t i p y r i n e t o r e a c t w i t h e i t h e r no-carrier-added 1311o r lZ5I-i n t h e presence o f c h l orami ne-T. P u r i f i c a t i o n o f 4-[ 13'I]i odoanti p y r i ne was performed by reversed-phase 1 i q u i d chromatography and r e s u l t e d i n a 99?1% radiochemically pure product i n an o v e r a l l 90% y i e l d . The use o f iodogen f o r o x i d a t i o n o f t h e r a d i o i o d i n e was a l s o investigated.