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Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation

✍ Scribed by Matthias Lotz; Tania Ireland; Katja Tappe; Paul Knochel

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 163 KB
Volume: 12
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(2000)12:5/6<389::aid-chir16>3.0.co;2-s

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✦ Synopsis

We have shown that the readily prepared (ferrocenyl)benzylic methyl ethers of type 1 can be ortho-metalated with tert-BuLi with high diastereoselectivity. This reaction has been used to prepare new borane-protected P,N-substituted ferrocenes of type 2 in high diastereomeric and enantiomeric purity. The chiral heterocyclic aminophosphines 2 may be of interest as chelating ligands for asymmetric metal catalysis.