Preparation of ketoprofen-loaded high-molecular-weight poly(vinyl alcohol) gels

✍ Scribed by Hyun Ju Lim; Sung Jun Lee; Han Gon Choi; Jung Ae Kim; Chul Soon Yong; Sung Soo Han; Seok Kyun Noh; Jinho Jang; Won Seok Lyoo

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 225 KB
• Volume: 106
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.25991

✦ Synopsis

Abstract

High‐molecular‐weight atactic poly(vinyl alcohol) (a‐PVA) gels loaded with (R,S)‐2‐(3‐benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a‐PVA with a number‐average degree of polymerization of 4000 in an ethylene glycol/water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a‐PVA gels. Then, the release behavior of ketoprofen from a‐PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a‐PVA gels increased. In addition, the enthalpy increased with an increase in the a‐PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007