Preparation of hydrophilic albumin microspheres using polymeric dispersing agents

✍ Scribed by William E. Longo; Hiroo Iwata; Thom A. Lindheimer; Eugene P. Goldberg

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 714 KB
• Volume: 71
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600711205

✦ Synopsis

It can be concluded from Tables 111 and IV that the antimicrobial activity of the normal series, in cannabichromene and cannabigerol homologs and isomers, is more pronounced than in case of the iso-series. Cannabichromene type compounds having a methyl or a pentyl group in the side chain show the highest antimicrobial activity. An intermediate type of activity is seen when R is a hydrogen. However, lengthening the side chain up to C1.5 leads to a tremendous decrease in activity. Total saturation of the two double bonds in the cannabichromene and cannabigerol type compounds having a methyl side chain in most of the cases leads to an increase in the antifungal and antibacterial activities as in the case of Compounds XI1 and V, respectively (Tables IV andV). This is the first reported synthesis and spectral data of most of the compounds prepared in this investigation. In addition, the antimicrobial activities of these compounds show encouraging results. The activities of the compounds prepared in this report were compared qualitatively with those of some known cannabinoids, namely, cannabigerol, cannabidiol, cannabicyclol, Asand A9-tetrahydrocannabinols and were found to be far superior in most instances (Tables I1 and111).