✦ LIBER ✦
Preparation of functionalized zinc and copper organometallics containing sulfur functionalities at the alpha or gamma position
✍ Scribed by Sidduri AchyuthaRao; Charles E. Tucker; Paul Knochel
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 282 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
a-Chloroalkyl phenyl sulfides 1 readily insert zinc in THF at 25 Oc (05-2 h), affording surfur stabilized organozinc derivatives of type 2. The presence of a functional group such as an ester or a cyan0 group is tolerated in these organometallics. After a transmelallation to the corresponding copper reagent 3, they react with a wide range of electrophiles. Zinc and copper organometallics bearing a thiophenyl or a phenylsulfinyl group at the yposition have also been prepared showing the generality of our approach.