Preparation of Fluorinated Linkers: Use of 19 F NMR Spectroscopy to Establish Conditions for Solid-Phase Synthesis of Pilicide Libraries
β Scribed by Svensson, Anette; Fex, Tomas; Kihlberg, Jan
- Book ID
- 126809258
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 166 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1520-4766
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π SIMILAR VOLUMES
Solid-phase synthesis is an attractive approach for the generation of large numbers of compounds for biological studies, for instance in the pharmaceutical industry. [1] In addition, automated procedures for solid-phase synthesis of oligopeptides and oligonucleotides have been of major importance in
## Abstract __N__β[1β(4β(4βfluorophenyl)β2,6βdioxocyclohexylidene)ethyl] (Fde) protected amino acids have been prepared and applied in solidβphase peptide synthesis monitored by gelβphase ^19^F NMR spectroscopy. The Fde protective group could be cleaved with 2% hydrazine or 5% hydroxylamine solutio