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Preparation of Finely Dispersed Drugs: III. Cyclosporine

✍ Scribed by Laurent Joguet; Egon Matijevi

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
309 KB
Volume
250
Category
Article
ISSN
0021-9797

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✦ Synopsis

Two different precipitation processes are described, which produced dispersions of spherical particles of cyclosporine ranging in diameter from approximately 10 nm to several micrometers. This drug is of interest for its immunosuppressive activity in the antirejection of transplanted organs. The effects of several experimental parameters on the average particles size and uniformity have been investigated. Aging of spherical particles resulted in large crystalline-type aggregates.

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