Preparation of Ferrocene-Containing Phosphinamine Ligands Possessing Central and Planar Chirality and Their Application in Palladium-Catalyzed Asymmetric Allylic Alkylation
β Scribed by Farrell, Annette; Goddard, Richard; Guiry, Patrick J.
- Book ID
- 126058698
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 129 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
We have shown that cymantrene derivatives are better P,N-chelate ligands for palladium-catalyzed allylic alkylation than ferrocenes, which have a similar pentagonal ligand structure to cymantrene derivatives. In particular, the PPh 3 -substituted cymantrene gave a higher enantioselectivity (>98%).
## Abstract For Abstract see ChemInform Abstract in Full Text.
Some novel ferrocenylphosphine-amidine ligands with central and planar chirality were prepared from (R,S p )-PPFNH 2 -R 3 and its diastereomer (S,S p )-PPFNH 2 3a. The efficiency and diastereomeric impact of these ferrocenylphosphine-amidine ligands in the palladium-catalyzed asymmetric allylic subs