Preparation of ethyl cellulose microcapsules containing perphenazine and polymeric perphenazine based on acryloyl chloride for physical and chemical studies of drug release control
✍ Scribed by Zandi, M.; Pourjavadi, A.; Hashemi, S. A.; Arabi, H.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 312 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0959-8103
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✦ Synopsis
The preparation of microcapsules containing perphenazine by solvent evaporation using ethyl cellulose is described. The microparticles are formed after solvent evaporation and polymer precipitation. The drug was dissolved in a polymer solution and emulsiÐed into an aqueous phase to form microcapsules.
To study the e †ects on particle size, encapsulation efficiency and morphology, three di †erent molecular weights of ethyl cellulose 71 000 and (M w \ 47 000, 99 000) were used. Covalent bonding of drugs to polymers via hydrolytically or enzymatically cleavable covalent bond was achieved for sustained drug delivery. The release rate of perphenazine from these systems was investigated. 1998 ( Society of Chemical Industry