Preparation of enantiopure Wieland–Miescher ketone and derivatives by the MαNP acid method. Substituent effect on the HPLC separation

MαNP acid, a powerful chiral molecular t

MαNP acid, a powerful chiral molecular tool for preparation of enantiopure alcohols by resolution and determination of their absolute configurations by the 1H NMR anisotropy method

✍ Yusuke Kasai; Hiromi Taji; Takuma Fujita; Yoko Yamamoto; Megumi Akagi; Akinori S 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 618 KB

## Abstract A novel methodology using a chiral molecular tool of MαNP acid (**1**), 2‐methoxy‐2‐(1‐naphthyl)propionic acid, useful for preparation of enantiopure secondary alcohols and determination of their absolute configurations by the ^1^H NMR anisotropy method was developed; racemic MαNP acid