Preparation of enantiomerically pure cis- and trans-N-(propionyl)hexahydrobenzoxazolidin-2-ones

✍ Scribed by Cecilia Anaya de Parrodi; Eusebio Juaristi; Leticia Quintero; Angel Clara-Sosa

• Book ID: 104361092
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 498 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00064-5

✦ Synopsis

A high-yield, five-step synthesis of novel enantiomerically pure cis-and trans-N-(propionyl)-hexahydrobenzoxazolidin-2-ones 5a--d from cyclohexene oxide and (S)-~methylbenzylamine is described. The highly diastereoselective benzylation of 5b is also described. (~) 1997 Elsevier Science Ltd