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Preparation of deuterium-labeled rutin by hydrogen exchange reaction

✍ Scribed by K. Hiraoka; T. Miyamoto; S. Baba; T. Furuta

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
258 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Preparation of deuterium‐labeled rutin by hydrogen exchange reaction under alkaline condition is described. Hydrogens at positions 2′, 5′ and 6′ of rutin were replaced with deuteriums only on heating, while hydrogens at positions 6 and 8 were readily replaced at room temperature. On the basis of these findings rutin‐2′, 5′, 6′, 6, 8‐d~5~ was first prepared and then treated with alkaline water at room temperature to obtain rutin labeled with deuteriums at positions 2′, 5′ and 6′.

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