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Preparation of deuterium-labeled monounsaturated and saturated fatty acids for use as stable isotope metabolic tracers

✍ Scribed by Sheldon N. Crane; Kevin Bateman; Sebastien Gagne; Jean-Francois Levesque

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 168 KB
Volume: 49
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1142

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✦ Synopsis

Abstract

Synthetic routes adaptable to the preparation of a variety of d~7~‐labeled monounsaturated and saturated fatty acids are reported. Using these reaction sequences, d~7~‐oleic [18:1 (9c)], d~7~‐elaidic [18:1 (9t)], and d~7~‐stearic acid (18:0) were prepared for use in metabolism studies as stable isotope‐labeled tracers. Copyright © 2006 John Wiley & Sons, Ltd.

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