Preparation of cystathionine sulfoxide and sulfone and some properties relating to their differentiation

✍ Scribed by Anne H. Datko; John Giovanelli; S. Harvey Mudd

• Publisher: Elsevier Science
• Year: 1975
• Tongue: English
• Weight: 249 KB
• Volume: 64
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(75)90407-8

✦ Synopsis

Methods are described for the oxidation of cystathionine to yield relatively pure preparations of either cystathionine sulfoxide (a mixture of the diastereoisomers) or of cystathionine sulfone. These products were shown to contain both the three and the four carbon moieties of cystathionine and were identified by their characteristic behavior during treatment with hydriodic acid or with oxidizing agent, and in the case of the sulfone, by elemental analysis. Paper and column chromatographic and electrophoretic mobilities of the sulfoxides and the sulfone were determined.