## Abstract Methyl __cis__,__cis__‐, __trans__,__cis__‐, __cis__,__trans__‐, and __trans__,__trans__‐12,15‐octadecadienoates‐9,10‐d~2~ were prepared by the Wittig Reaction between __cis__‐ or __trans__‐3‐hexenyltriphenylphosphonium bromide and methyl 12‐oxododecanoate‐9,10‐d~2~ with butyl lithium i
Preparation of cis and trans-α-d-3-alkenoic acids
✍ Scribed by S. Safe; C. Penney
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- French
- Weight
- 140 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
The role of by unsaturated fatty acids has become significant in the biochemistry of plants and microorganisms. The isolation of trans-3-hexadecenoic acid from plants (1-3) and photosynthetic microorganisms (*-w may indicate a possible role for this acid in some aspect of photosynthesis. Bloch and co-workers ('4) have also shown the importance of trans-3-decenoic acid as a key intermediate in the synthesis of unsaturated fatty acids via the anaerobic pathway. It was therefore of interest to prepare a series of labelled py-* Issued as NRCC No. 11883.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The high efficiency of the title synthesis permits a multigram preparation of the amino acids (VII) and (VIII) which are the simplest cyclic conformationally restricted γ‐aminobutyric acid analogues.
## Abstract A method is described for the synthesis of the racemic [methyl‐d~3~] forms of the nicotine metabolites __cis__‐3′‐hydroxycotinine and __trans__‐3′‐hydroxycotinine. The key intermediate was [methyl‐d~3~]‐N‐methylhydroxylamine, obtained from a selective hydrogenation of d~3~‐nitro‐methane