Preparation of carboxy-PEG-PLA nanoparticles loaded with camptothecin and their body distribution in solid tumor–bearing mice

PLA nanoparticles loaded with an active

PLA nanoparticles loaded with an active lactone form of hydroxycamptothecin: Development, optimization, and in vitro–in vivo evaluation in mice bearing H22 solid tumor

✍ Zhenqing Hou; Chunxiao Zhou; Ying Luo; Chuanming Zhan; Yixiao Wang; Liya Xie; Qi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

## Abstract Hydroxycamptothecin (HCPT)‐loaded PLA nanoparticles were prepared by a one‐step method using the direct dialysis technique, and were examined for particle characteristics, in vitro drug release, and cytotoxicity, as well as antitumor efficiency. Three main influential factors based on t