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Preparation of carbon-14 labelled guazatine (1,17-BIS- [14C]-guanidino-9-azaheptadecane triacetate)

✍ Scribed by H. R. Hudson; M. Pianka; Mrs. L. Powroznik; V. P. Lynch

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
160 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1,17‐Bisguanidino‐9‐azaheptadecane triacetate(Guazatine)has been prepared with carbon‐14 labelling of the guanidine carbon atoms, by interaction of 1,17‐diamino‐9‐azaheptadecane with S‐methyl‐ ^14^C ‐isothiouronium sulphate. The initial product was purified by precipitation as the carbonate which was then dissolved in aqueous acetic acid to give a 6 % solution of the triacetate, with specific activity of 20.8 μCi mmol^−l^.

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## Abstract 1,1‐Bis[4‐(1‐carboxy‐l‐methylpropoxy)phenyl]cyclahexane (S‐8527) (I), a new hypolipaemic agent, was labelled at C‐2 with carbon‐14 for the use of metabolic studies. The procedure used is illustrated in Fig. 1. Cyclohexane‐2‐^14^C which was prepared from potassium cyanide‐^14^C was conde